Related Experiment Video
Updated: Jun 11, 2025
High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
Reproducibility of myocardial extracellular volume quantification using dual-energy computed tomography in patients
Yoshito Kadoya1, Mehmet Onur Omaygenc1, Benjamin Chow1
1Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, K1Y 4W7, Canada.
Background:
Quantifying myocardial extracellular volume (ECV) using computed tomography (CT) has been shown to be useful in the evaluation of cardiac amyloidosis. However, the reproducibility of CT measurements for myocardial ECV, is not well-established in patients with proven cardiac amyloidosis.
Methods:
This prospective single-center study enrolled cardiac amyloidosis patients to undergo dual-energy CT for myocardial fibrosis assessment. Delayed imaging at 7 and 8 min post-contrast and independent evaluations by two blinded cardiologists were performed for ECV quantification using 16-segment (ECVglobal) and septal sampling (ECVseptal). Inter- and intraobserver variability and test-retest reliability were measured using Spearman's rank correlation, Bland-Altman analysis, and intraclass correlation coefficients (ICC).
Results:
Among the 24 participants (median age = 78, 67 % male), CT ECVglobal and ECVseptal showed median values of 53.6 % and 49.1 % at 7 min, and 53.3 % and 50.1 % at 8 min, respectively. Inter- and intraobserver variability and test-retest reliability for CT ECVglobal (ICC = 0.798, 0.912, and 0.894, respectively) and ECVseptal (ICC = 0.791, 0.898, and 0.852, respectively) indicated good reproducibility, with no evidence of systemic bias between observers or scans.
Conclusions:
Dual-energy CT-derived ECV measurements demonstrated good reproducibility in patients with proven cardiac amyloidosis, suggesting potential utility as a repeatable imaging biomarker for this disease.
