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Published on: August 6, 2019
Association Between Circulating Inflammatory Cytokines and Dentofacial Anomalies
Yuxiao Zhang1, Zhihao Wen1, Xiangyao Wang1
1Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, China.
This study used Mendelian randomization to investigate inflammatory cytokines and dentofacial anomalies (DA). Certain cytokines were linked to DA risk, suggesting inflammation plays a role in DA development.
Area of Science:
- Genetics
- Immunology
- Oral and Maxillofacial Surgery
Background:
- Inflammatory cytokines are implicated in dentofacial anomalies (DA), but causal links remain unclear.
- Understanding the relationship between inflammation and DA is crucial for etiology and treatment.
Purpose of the Study:
- To investigate the causal relationship between circulating inflammatory cytokines and dentofacial anomaly (DA) risk.
- Utilize Mendelian randomization to analyze genetic associations.
Main Methods:
- Employed a two-way, two-sample Mendelian randomization analysis.
- Utilized genome-wide association study data for 91 inflammatory cytokines and dentofacial anomaly (DA) summary statistics.
- Performed inverse variance weighting and sensitivity analyses for robust findings.
Main Results:
- Identified five cytokines inversely associated with DA prevalence.
- Found associations between DA and specific fibroblast growth factors (FGFs), interleukin (IL) variants, and urokinase-type plasminogen activator.
- Validated findings using protein quantitative trait loci data.
Conclusions:
- Substantiated a significant association between inflammatory cytokines and dentofacial anomalies (DA).
- Highlighted the pivotal role of inflammation in the etiology of DA.
- Provided a genetic basis for inflammation's role in DA, suggesting new diagnostic and therapeutic targets.
