Related Experiment Video

Updated: Jun 11, 2025

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

2.2K

Association between consensus-based nutrition pathway and growth faltering in infants with gastroschisis: A

Katie M Strobel1,2, Katelin Kramer3, Catherine Rottkamp4

  • 1Department of Pediatrics, University of California Los Angeles, Los Angeles, California, USA.

JPEN. Journal of Parenteral and Enteral Nutrition
|October 6, 2024
PubMed

Insights

A new nutrition pathway significantly reduced growth faltering in infants with gastroschisis. This multicenter approach improved infant outcomes by focusing on early parenteral nutrition and human milk, leading to better growth by hospital discharge.

Area of Science:

  • Pediatric Surgery
  • Neonatal Nutrition
  • Growth Monitoring

Background:

  • Gastroschisis is associated with a high incidence of growth faltering, affecting 55% of infants by hospital discharge.
  • A significant need exists to improve nutritional support and growth outcomes for neonates with gastroschisis.
  • Previous research highlighted the challenges in managing growth faltering in this population.

Purpose of the Study:

  • To assess the adherence and efficacy of a newly developed nutrition pathway for infants with gastroschisis.
  • To evaluate the impact of the pathway on growth faltering rates at hospital discharge.
  • To compare growth outcomes in infants before and after the pathway's implementation.

Main Methods:

  • A multicenter nutrition pathway was developed and implemented across six California hospitals.
  • The pathway emphasized early parenteral macronutrient provision, human milk utilization, and specific growth faltering treatments.
  • Infants born before (n=126) and after (n=52) pathway initiation were compared for weight and linear growth faltering (z score decline ≥0.8).

Main Results:

  • Adherence to the pathway components ranged from 58% to 95%.
  • The incidence of weight or linear growth faltering at discharge decreased significantly post-pathway implementation (59.4% vs 36.2%, P=0.0068).
  • The pathway was independently associated with reduced growth faltering (OR 0.35) and linear growth faltering (OR 0.24) at discharge, after adjusting for gestational age and fetal growth restriction.

Conclusions:

  • Implementation of a multicenter nutrition pathway led to a significant reduction in growth faltering for infants with gastroschisis.
  • The pathway effectively improved infant growth outcomes by hospital discharge.
  • This standardized approach demonstrates a successful strategy for managing nutritional challenges in gastroschisis.
Abstract

Keywords:
gastroschisisgrowthnutrition

More Related Videos

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation09:02

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

19.4K
Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

531

Related Concept Videos

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
84
Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.4K
Enteral Nutrition I: Orogastric and Nasogastric Feeding01:26

Enteral Nutrition I: Orogastric and Nasogastric Feeding

Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
214
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
142
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
894
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
802