[Use of platelet-rich fibrin in periodontal surgery]

Periodontal disease as a chronic inflammation of multifactorial origins causes the destruction of the supporting tissues of the teeth. Due to intraosseal defects, the prognosis of the affected teeth is questionable. Comprehensive periodontal therapy intends to stop the destruction of the attachment apparatus and reach the regeneration of lost tissues. Periodontal intrabony defects have shown improved regenerative potential due to their morphology. Interest in the use of biological agents to promote periodontal regeneration, including growth factors, has increased significantly in recent decades. Autologous platelet concentrates have been successfully applied in various fields of medicine for more than two decades. Autologous platelet concentrates are being used in more and more areas of medicine. Application of platelet-rich fibrin is the most topical among these therapeutic options. As main advantages, it can be prepared without the addition of anticoagulants, requires only one centrifugation, its high concentration of growth factors is highly supportive for wound healing and can be used in various forms. The application of platelet-rich fibrin may facilitate the successful treatment of periodontal defects. A new generation of platelet-rich fibrin may open up further opportunities, including those in periodontal wound healing. Orv Hetil. 2024; 165(40): 1570–1578.