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Vaginal Microflora in High Vaginal Swab in Prelabour Rupture of Membrane: A Descriptive Cross-sectional Study
Jyotshna Sharma1, Sanjeeb Tiwari2, Durga Thapa1
1Department of Obstetrics and Gynaecology, Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.
JNMA; Journal of the Nepal Medical Association
|October 6, 2024
Summary
Premature rupture of membranes (PROM) is linked to cervicovaginal infections. This study identified E. coli as the most common pathogen in PROM cases, guiding antibiotic selection for better maternal and infant outcomes.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Microbiology
Background:
- Premature rupture of membranes (PROM) is the disruption of fetal membranes before labor onset, leading to amniotic fluid leakage.
- Cervicovaginal infections are a significant risk factor for PROM, potentially causing adverse maternal and neonatal complications.
Purpose of the Study:
- To identify prevalent bacterial pathogens in antenatal women experiencing PROM.
- To inform the selection of appropriate antibiotics for treating PROM-associated infections.
Main Methods:
- A descriptive cross-sectional study was conducted over six months.
- High vaginal swabs were collected from 117 antenatal women diagnosed with PROM for microbial culture and sensitivity testing.
- Data were analyzed using SPSS software.
Main Results:
- Microbial growth was detected in 19.66% (23/117) of the collected samples.
- Nine different pathogens were identified, with Escherichia coli (E. coli) being the most frequent (52.17%), followed by Klebsiella (17.39%) and Pseudomonas (8.70%).
Conclusions:
- Diverse microorganisms are implicated in PROM cases, with E. coli being predominant.
- Understanding these bacterial patterns is crucial for effective antibiotic therapy, aiming to improve maternal and neonatal health outcomes.
- Early detection and treatment of vaginal infections in PROM cases can reduce morbidity and mortality.
