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Related Experiment Videos

Intestinal Inflammation and Permeability in Patients Recovered from SARS-CoV-2 Infection.

Antonella Gallo1, Celeste Ambra Murace2, Michela Maria Corbo3

  • 1Department of Geriatrics and Orthopedics, Fondazione Policlinico Universitario "A. Gemelli," IRCCS, Rome, Italy.

Digestive Diseases (Basel, Switzerland)
|October 6, 2024
PubMed
Summary

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Antibiotics (Basel, Switzerland)·2024
This summary is machine-generated.

Long COVID gastrointestinal symptoms are not strongly linked to local inflammation. Further research into post-infection disorders of gut-brain interaction is crucial for better patient management.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Immunology

Background:

  • Long COVID gastrointestinal (GI) issues are linked to post-infection disorders of gut-brain interaction (PI-DGBIs).
  • Mechanisms behind long-term GI sequelae post-SARS-CoV-2 infection remain unclear.
  • This study investigates intestinal inflammation and permeability in recovered individuals.

Purpose of the Study:

  • To assess intestinal inflammation and permeability in SARS-CoV-2 survivors.
  • To correlate these factors with long-term GI sequelae.
  • To evaluate the presence of PI-DGBIs using Rome IV criteria.

Main Methods:

  • Eighty-six recovered SARS-CoV-2 subjects were assessed 6 months post-infection.
  • Fecal calprotectin (FC) measured intestinal inflammation; serum and fecal zonulin measured intestinal permeability.
Keywords:
Disorders of gut-brain interactionGastrointestinal sequelaeIntestinal inflammationIntestinal permeabilityLong COVID

Related Experiment Videos

  • Rome IV, HADS, and GIQLI questionnaires assessed GI symptoms, anxiety/depression, and quality of life.

    • Main Results:

    • 43% of subjects reported long-term GI symptoms; 33 met Rome IV criteria for PI-DGBIs.
    • Higher FC levels were observed in asymptomatic subjects (p=0.03), but remained near normal.
    • No significant differences in intestinal permeability were found; GIQLI showed an inverse correlation between GI sequelae and quality of life (p=0.009).

    Conclusions:

    • Long COVID GI complaints may not stem from local inflammatory processes.
    • Understanding post-COVID PI-DGBIs is vital due to their significant health and societal impact.
    • Further research is encouraged to improve the management of these emerging conditions.