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Related Concept Videos

Aggression01:47

Aggression

Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for hire...
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

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Related Experiment Video

Updated: Jul 8, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

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Mapping Lesion-Related Human Aggression to a Common Brain Network.

Shaoling Peng1, Frederic L W V J Schaper2, Shira Cohen-Zimerman3

  • 1Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Biological Psychiatry
|October 6, 2024
PubMed
Summary

Brain lesions linked to aggression form a specific network, primarily connected to the right prefrontal cortex. This finding identifies potential targets for treating aggression and related neuropsychiatric symptoms.

Keywords:
AggressionBrain lesionCriminalityDBSFunctional connectivityIrritabilityLesion network mappingfMRI

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Area of Science:

  • Neuroscience
  • Neurobiology
  • Psychiatry

Background:

  • Aggression poses a significant societal burden and is common in neuropsychiatric disorders.
  • The underlying neural mechanisms of aggression remain poorly understood, limiting effective treatment options.

Purpose of the Study:

  • To identify the neural network associated with aggression using lesion network mapping.
  • To investigate the relationship between damage to this network and aggression-related symptoms.
  • To explore the therapeutic potential of this network for neuromodulation.

Main Methods:

  • Utilized lesion network mapping on data from 182 Vietnam War veterans with penetrating head injuries.
  • Validated findings using the Harvard Lesion Repository (N=852) to assess aggression-related neuropsychiatric symptoms.
  • Examined a deep brain stimulation dataset (N=25) in epilepsy patients to explore therapeutic relevance.

Main Results:

  • Aggression-associated lesions map to a specific network with a hub in the right prefrontal cortex.
  • This network shows distinct patterns of positive and negative functional connectivity with various brain regions.
  • Criminality exhibited the strongest alignment with the aggression network among 24 neuropsychiatric symptoms; deep brain stimulation connectivity correlated with irritability.

Conclusions:

  • Brain lesions linked to aggression define a specific human brain circuit.
  • Functionally connected regions within this circuit offer potential targets for therapeutic neuromodulation.