Associations between peripheral whole blood cell counts derived indexes and cancer prognosis: An umbrella review of meta-analyses of cohort studies
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View abstract on PubMed
Summary
This summary is machine-generated.This umbrella review assessed whole blood cell count indexes and cancer prognosis. While some associations show suggestive evidence, inconsistent effect sizes necessitate further research for definitive conclusions.
Area Of Science
- Oncology
- Hematology
- Biostatistics
Background
- Conflicting meta-analyses exist on whole blood cell count (WBCC) derived indexes and cancer prognosis.
- Indexes include neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR).
- The aggregate strength and quality of evidence require quantification.
Purpose Of The Study
- To grade the evidence from published meta-analyses of cohort studies.
- Investigate associations between NLR, PLR, LMR, and cancer prognosis.
- Summarize existing evidence on WBCC-derived indexes and cancer outcomes.
Main Methods
- Umbrella review methodology.
- Inclusion of 694 associations from 224 articles.
- Quality assessment using AMSTAR, with 97.8% rated moderate-to-high.
Main Results
- Four associations demonstrated convincing evidence.
- 165 associations had highly suggestive evidence.
- 164 associations showed suggestive evidence.
Conclusions
- Existing evidence on WBCC-derived indexes and cancer prognosis is summarized.
- Inconsistent effect size directions across studies indicate a need for further research.
- Causality and firm evidence require additional investigation.
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