Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

1.0K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.0K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

1.3K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.3K
Development of the Lymphatic System01:15

Development of the Lymphatic System

571
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
571
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

1.4K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
1.4K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

1.4K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
1.4K
Ovaries01:26

Ovaries

720
The ovaries are roughly the size of almonds and measure approximately 2 to 3 centimeters in length. These paired structures are situated within the pelvic region and are anchored by the mesovarium—a peritoneal extension that also connects them to the wider structure of the broad ligament. The support system extends to the suspensory ligament, housing blood and lymphatic vessels. In addition, the ovarian ligament tethers the ovaries to the uterus.
On the ovarian surface, a layer of...
720

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contributions of T-helper 9 cells in endometriosis-associated inflammation and lesion growth.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Correction: Misregulated alternative splicing in endometriosis: a role for aberrant mRNA variants in endometriotic cell growth.

Cell death discovery·2026
Same author

Immune dysregulation in endometriosis: the T cell perspective.

Frontiers in immunology·2026
Same author

Misregulated alternative splicing in endometriosis: a role for aberrant mRNA variants in endometriotic cell growth.

Cell death discovery·2026
Same author

Efficient self-supervised Barlow Twins from limited tissue slide cohorts for colonic pathology diagnostics.

Medical image analysis·2026
Same author

Editorial Comment.

The Journal of urology·2025

Related Experiment Video

Updated: Jun 11, 2025

Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
08:02

Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue

Published on: January 6, 2012

28.6K

Tertiary lymphoid structures in endometriosis.

Katherine B Zutautas1, Priyanka Yolmo2, Minqi Xu3

  • 1Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.

F&S Science
|October 6, 2024
PubMed
Summary
This summary is machine-generated.

Tertiary lymphoid structures (TLSs) were found in endometriosis lesions, with mature TLSs in ectopic tissues and immature TLSs in eutopic and control samples. This suggests TLSs are common in endometriosis and warrant further study.

Keywords:
Tertiary lymphoid structuresautoimmunitychronic inflammationendometriosis

More Related Videos

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

11.3K
A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
07:12

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

5.1K

Related Experiment Videos

Last Updated: Jun 11, 2025

Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
08:02

Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue

Published on: January 6, 2012

28.6K
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

11.3K
A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
07:12

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

5.1K

Area of Science:

  • Immunology
  • Gynecologic Pathology
  • Histopathology

Background:

  • Tertiary lymphoid structures (TLSs) are organized immune cell aggregates found in non-lymphoid tissues.
  • The presence and role of TLSs in endometriosis, a chronic inflammatory gynecologic condition, are not fully understood.

Purpose of the Study:

  • To investigate the consistent presence of tertiary lymphoid structures (TLSs) in endometriosis lesions.
  • To characterize the cellular composition and morphology of TLSs in endometriosis.

Main Methods:

  • Histopathological analysis of endometrial and lesion tissues from 113 endometriosis patients and 110 controls.
  • Multiplex immunofluorescence to identify canonical TLS cell populations (T-cells, B-cells, dendritic cells, high endothelial venules).

Main Results:

  • Mature TLSs were identified in ectopic endometriosis tissue samples (ovary, fallopian tube).
  • Immature TLSs, lacking follicular dendritic cell networks and high endothelial venules, were observed in eutopic and control endometrial samples.
  • TLSs were consistently detected across different endometriosis phenotypes.

Conclusions:

  • Tertiary lymphoid structures are present in various endometriosis phenotypes.
  • Further research is needed to understand the role of TLSs in endometriosis pathophysiology and their prognostic value.