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Updated: Jun 11, 2025

A Genetic Screen to Isolate Toxoplasma gondii Host-cell Egress Mutants
Published on: February 8, 2012
Involvement of extracellular vesicles in the interaction of hosts and Toxoplasma gondii
Letícia Pereira Pedrini Vicentini1, Vera Lucia Pereira-Chioccola2, Blima Fux3
1Programa em Doenças Infecciosas, Centro de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil.
Abstract:
Toxoplasma gondii, the causative agent of toxoplasmosis, is widely distributed. This protozoan parasite is one of the best adapted, being able to infect innumerous species of animals and different types of cells. This chapter reviews current literature on extracellular vesicles secreted by T. gondii and by its hosts. The topics describe the life cycle and transmission (1); toxoplasmosis epidemiology (2); laboratorial diagnosis approach (3); The T. gondii interaction with extracellular vesicles and miRNAs (4); and the perspectives on T. gondii infection. Each topic emphases the host immune responses to the parasite antigens and the interaction with the extracellular vesicles and miRNAs.
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