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Related Concept Videos

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

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Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
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Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

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Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
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Overview of Exosomes01:36

Overview of Exosomes

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Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
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Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

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Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
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Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

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Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
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Sleep-Wake Cycles01:24

Sleep-Wake Cycles

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Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
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Related Experiment Video

Updated: Jun 11, 2025

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
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A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

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Extracellular vesicles and sleep deprivation.

Ronni Rômulo Novaes E Brito1

  • 1Centro Universitário São Camilo, São Paulo, Brazil.

Current Topics in Membranes
|October 6, 2024
PubMed
Summary
This summary is machine-generated.

Adequate sleep is crucial for physical and mental health. Sleep deprivation impacts health and may involve extracellular vesicles (EVs) in its effects on various conditions.

Keywords:
Apoptotic bodiesExosomesExtracellular vesiclesImmunosuppressionMicrovesiclesSleep deprivation

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Establishing a Device for Sleep Deprivation in Mice
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Establishing a Device for Sleep Deprivation in Mice
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Area of Science:

  • Sleep science
  • Cell biology
  • Biomedical research

Background:

  • Sleep is essential for recovery, immunity, hormone regulation, and cognitive functions.
  • Sleep deprivation affects 20% of adults, impairing performance and health.
  • Sleep deprivation can lead to stress, hyperglycemia, and hypertension.

Purpose of the Study:

  • To explore the role of extracellular vesicles (EVs) in sleep-related conditions.
  • To understand how sleep deprivation influences EV release and function.
  • To identify potential therapeutic targets related to sleep and EVs.

Main Methods:

  • Review of recent research on sleep, sleep deprivation, and extracellular vesicles.
  • Analysis of studies investigating the impact of sleep deprivation on EV release.
  • Examination of the link between EVs and health outcomes affected by sleep.

Main Results:

  • Sleep deprivation alters extracellular vesicle (EV) release.
  • EVs are implicated in cancer progression, inflammation, and thrombosis risk.
  • EVs may mediate some adverse health effects of sleep deprivation.

Conclusions:

  • Extracellular vesicles (EVs) are involved in intercellular communication and may play a role in sleep disorders.
  • Understanding EV mechanisms in sleep deprivation offers insights into therapeutic interventions.
  • Multidisciplinary research is needed to address sleep, EVs, and health complexities.