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Updated: Jun 11, 2025

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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Cutaneous Chronic Graft-Versus-Host Disease: Clinical Manifestations, Diagnosis, Management, and Supportive Care

Connie R Shi1, Alana L Ferreira2, Manjit Kaur3

  • 1Center for Cutaneous Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.

Transplantation and Cellular Therapy
|October 6, 2024
PubMed

Insights

Cutaneous chronic graft-versus-host disease (cGVHD) presents varied skin symptoms after stem cell transplants. Early diagnosis and multidisciplinary care, including dermatology, are crucial for managing cGVHD and improving patient quality of life.

Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Cutaneous chronic graft-versus-host disease (cGVHD) significantly impacts patient morbidity, mortality, and quality of life post-hematopoietic stem cell transplantation.
  • Clinical presentations of cGVHD are diverse, categorized as nonsclerotic or sclerotic.

Purpose of the Study:

  • To provide a comprehensive review of cutaneous cGVHD.
  • To highlight unique challenges in diagnosing and managing cGVHD in skin of color.
  • To outline long-term dermatologic care strategies for cGVHD survivors.

Main Methods:

  • Literature review focusing on clinical presentation, diagnosis, grading, and treatment of cGVHD.
  • Emphasis on underrepresented data concerning cGVHD in skin of color.
  • Inclusion of long-term skin care recommendations.

Main Results:

  • cGVHD diagnosis and management require careful consideration of varied clinical features.
  • Skin of color presentations are often unique and may lead to diagnostic delays.
  • Integrated, multidisciplinary care is essential for optimal outcomes.

Conclusions:

  • Effective management of cutaneous cGVHD necessitates a thorough understanding of its diverse presentations.
  • Addressing disparities in cGVHD research and care for skin of color is critical.
  • Ongoing dermatologic support is vital for patients recovering from cGVHD.

Keywords:
Cutaneous graft versus host disease

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