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Updated: Jun 11, 2025

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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Successful Treatment of Monoclonal Immunotactoid Glomerulopathy Associated with Chronic Lymphocytic Leukemia Using

Ayano Saito1, Yoshihiro Kameoka1, Kumi Ubukawa2

  • 1Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|October 6, 2024
PubMed

A 71-year-old woman developed nephrotic syndrome during 10-year follow-up for chronic lymphocytic leukemia. A renal biopsy sample analysis revealed IgG1-lambda-positive monoclonal immunotactoid glomerulopathy (mITG). The patient was treated with ibrutinib, a Bruton tyrosine kinase inhibitor, and complete renal remission was achieved after 24 months. ITG is a rare disease that is characterized by glomerular deposition. In particular, mITG, which presents immune deposits that exhibit light-chain restriction, is often associated with hematologic disorders. Most patients with mITG receive immunosuppressive therapy and/or chemotherapy; however, to our knowledge, there have been no reports of treatment with ibrutinib.

Keywords:
Bruton's tyrosine kinase inhibitorIgG1-lambda monoclonal gammopathychronic lymphocytic leukemiaibrutinibimmunotactoid glomerulopathynephrotic syndrome

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