Autophagy as a targeted therapeutic approach for skin cancer: Evaluating natural and synthetic molecular...

Area of Science:

• Oncology
• Cell Biology
• Biochemistry

Background:

• Skin cancer is a widespread malignancy with increasing incidence.
• Autophagy, a cellular degradation process, plays a dual role in skin cancer development and progression.
• Modulating autophagy presents significant therapeutic potential for skin cancer treatment.

Purpose of the Study:

• To systematically review the relationship between skin cancer and autophagy.
• To investigate the contribution and mechanisms of autophagy modulators in skin cancer.
• To evaluate the effectiveness and safety of autophagy modulation as a therapeutic strategy.

Main Methods:

• Systematic literature review.
• Analysis of existing research on autophagy modulators in skin cancer.
• Elucidation of physiological mechanisms of action for identified compounds.

Main Results:

• A diverse range of autophagy modulators show promise for skin cancer treatment.
• Each compound acts through distinct, elucidated physiological mechanisms.
• No notable adverse effects were reported for natural, synthetic, or semisynthetic compounds in human or animal models.

Conclusions:

• Targeting autophagy is a promising therapeutic strategy for skin cancer.
• Autophagy modulators offer novel mechanistic and therapeutic perspectives.
• The safety profile of these modulators suggests a viable clinical approach.