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Updated: Jun 11, 2025

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
Published on: January 23, 2018
Mechanochemistry for Organic and Inorganic Synthesis
Javier F Reynes1, Felix Leon2, Felipe García3
1Departamento de Química Orgánica e Inorgánica. Facultad de Química. Universidad de Oviedo. Ave. Julián Clavería 8, 33006 Oviedo, Asturias Spain.
Abstract:
In recent years, mechanochemistry has become an innovative and sustainable alternative to traditional solvent-based synthesis. Mechanochemistry rapidly expanded across a wide range of chemistry fields, including diverse organic compounds and active pharmaceutical ingredients, coordination compounds, organometallic complexes, main group frameworks, and technologically relevant materials. This Review aims to highlight recent advancements and accomplishments in mechanochemistry, underscoring its potential as a viable and eco-friendly alternative to conventional solution-based methods in the field of synthetic chemistry.
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