Radiation-Induced Angiosarcoma Arising in Bilateral Breast: A Case Report.

Area of Science:

• Oncology
• Radiation Oncology
• Surgical Oncology

Background:

• Radiation-induced angiosarcoma is a rare but aggressive malignancy.
• Angiosarcoma can develop years after radiation therapy for breast cancer.
• This case presents a unique challenge in managing late-onset, bilateral radiation-induced angiosarcoma.

Observation:

• A patient developed bilateral breast angiosarcoma seven years after partial mastectomy and radiation therapy.
• Initial treatment involved wide resection with skin grafting and taxane-based chemotherapy.
• Chemotherapy was discontinued due to drug-induced pneumonia.

Findings:

• Despite aggressive surgical and chemotherapeutic interventions, the angiosarcoma recurred rapidly 18 months postoperatively.
• Recurrence involved subcutaneous tissue, lymph nodes, lungs, and bones.
• The patient's disease progressed quickly, leading to death two months after recurrence.

Implications:

• This case underscores the aggressive nature and poor prognosis of radiation-induced angiosarcoma.
• It highlights the challenges in managing treatment-related complications, such as chemotherapy-induced pneumonia.
• Further research into optimal treatment strategies and long-term surveillance for radiation-induced angiosarcoma is warranted.