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Exploring The Prognostic Role Of D-dimer Levels In Pancreatic Cancer: A Comprehensive Review Of Clinicopathological Associations.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Exploring The Prognostic Role Of D-dimer Levels In Pancreatic Cancer: A Comprehensive Review Of Clinicopathological Associations.

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Exploring the Prognostic Role of D-dimer Levels in Pancreatic Cancer: A Comprehensive Review of Clinicopathological Associations.

Sparsh Dixit¹, Chandrashekhar Mahakalkar¹, Shivani Kshirsagar¹

¹General Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

|October 7, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Elevated D-dimer levels indicate a poorer prognosis for pancreatic cancer patients. This fibrin degradation product may serve as a valuable prognostic biomarker for improved patient outcomes.

Keywords:

coagulation d-dimer pancreatic cancer prognostic biomarker

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Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Published on: November 5, 2020

Area of Science:

Oncology
Hematology
Biomarker Research

Background:

Pancreatic cancer has a poor prognosis due to late diagnosis and aggressive progression.
Prognostic biomarkers are essential for improving patient outcomes and treatment strategies.
D-dimer, a fibrin degradation product, is associated with coagulation abnormalities and shows potential as a cancer biomarker.

Purpose of the Study:

To comprehensively review the prognostic role of D-dimer levels in pancreatic cancer.
To synthesize current research on D-dimer and its clinicopathological associations in pancreatic cancer.
To explore the potential utility of D-dimer as a prognostic marker for pancreatic cancer.

Main Methods:

Systematic review and synthesis of existing research on D-dimer levels in pancreatic cancer.

survival outcomes

tumor progression

Analysis of clinicopathological associations between D-dimer and tumor characteristics (stage, grade, metastasis).

Evaluation of methodological challenges and standardization needs for D-dimer measurement.

Main Results:

Elevated D-dimer levels in pancreatic cancer patients correlate with poorer clinical outcomes.
Higher D-dimer levels are associated with reduced overall survival and increased disease progression.
D-dimer levels show correlations with tumor stage, grade, and metastatic spread.

Conclusions:

D-dimer shows potential as a prognostic biomarker in pancreatic cancer, linked to adverse outcomes.
Standardized measurement protocols are needed to enhance the reliability of D-dimer as a biomarker.
Further research is required to validate D-dimer's clinical utility for risk stratification and personalized treatment planning.