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The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
08:47

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia

Published on: November 19, 2008

35.7K

Multicystic encephalopathy: an ultimate manifestation of ischemic-hypoxic injury

Vielka Fernandez Aragones1, Amilcar Castellano-Sanchez1,2, Gabriel Chamyan3

  • 1Mount Sinai Medical Center, Arkadi M. Rywlin Department of Pathology and Laboratory Medicine, Miami Beach, FL, USA.

Autopsy & Case Reports
|October 7, 2024
PubMed

Insights

Multicystic encephalopathy, a rare brain condition in infants, involves cystic lesions from oxygen deprivation. This case report details a unique infant presentation with congenital heart defects and other health issues.

Area of Science:

  • Neurology
  • Pediatrics
  • Neonatology

Background:

  • Multicystic encephalopathy is a rare neurological disorder in neonates and infants.
  • It is characterized by multiple cystic lesions resulting from hypoxic-ischemic injury.
  • Repetitive episodes of oxygen deprivation are the primary cause.

Observation:

  • A rare case of multicystic encephalopathy is presented in a 3-month-old male infant.
  • The infant was born prematurely at 34 weeks gestation.
  • The infant had Tetralogy of Fallot and multiple comorbidities.

Findings:

  • Autopsy revealed multiple irregular cystic lesions in the brain.
  • Significant distortion of the brain parenchyma was observed.
  • Histopathologic findings are discussed in the literature review.

Implications:

  • This case highlights the unique presentation of multicystic encephalopathy.
  • It underscores the importance of considering hypoxic-ischemic injury in infants with complex comorbidities.
  • The report provides a comprehensive review of the condition's etiology, clinical aspects, and pathology.
Keywords:
AutopsyBrainHypoxia, Infant, Newborn

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