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Patient-Reported Racial and Ethnic Disparities in Patients With Ulcerative Colitis: Results From the National Health
Sabree C Burbage1, Kathryn L Krupsky2, M Janelle Cambron-Mellott3
1Population Health Research, Janssen Scientific Affairs, LLC, Horsham, PA, USA.
Ulcerative colitis (UC) patients with moderate/severe disease experience worse health-related quality of life and higher costs. Racial/ethnic disparities exist, with Hispanic patients showing unique employment challenges related to UC severity.
Area of Science:
- Gastroenterology
- Health Economics
- Health Services Research
Background:
- Ulcerative colitis (UC) is a chronic inflammatory condition impacting quality of life.
- Limited research exists on patient-reported and economic outcomes across UC severity and racial/ethnic groups.
Purpose of the Study:
- To assess sociodemographic, patient-reported, and economic outcomes in UC patients.
- To examine associations between UC severity, race/ethnicity, and health outcomes.
Main Methods:
- Cross-sectional study using National Health and Wellness Survey data (2018-2020).
- Multivariable analyses assessed UC severity and race/ethnicity impact on HRQoL, WPAI, HCRU, and costs.
- Included 1500 UC participants: 1150 non-Hispanic White, 99 non-Hispanic Black, 251 Hispanic.
Main Results:
- Moderate/severe UC linked to worse HRQoL, WPAI, HCRU, and higher medical costs than mild UC.
- Non-Hispanic Black participants reported better HRQoL; Hispanic participants reported higher HCRU and costs compared to non-Hispanic White participants.
- Race/ethnicity interacted with UC severity in predicting labor force participation.
Conclusions:
- Moderate/severe UC significantly worsens patient outcomes and increases healthcare utilization and costs.
- Racial/ethnic differences in HRQoL, employment, and economic burden are evident.
- Hispanic patients exhibit distinct patterns in how UC severity affects employment; further research is needed.
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