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Updated: Jun 11, 2025

Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay

Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay

Published on: May 12, 2020

EVALUATION OF OXIDATIVE STRESS MARKERS IN GIRLS WITH PREMATURE THELARCHE AND PRECOCIOUS PUBERTY.

S Odabasi Gunes¹, O Akin¹, N Durmaz²

¹Department of Pediatric Endocrinology, UHS Gulhane Training and Research Hospital, Ankara, Turkey.

Acta Endocrinologica (Bucharest, Romania : 2005)

|October 7, 2024

Summary

Thiol-disulfide homeostasis is altered in girls with premature thelarche and precocious puberty. Native thiol and total thiol levels can help distinguish these conditions from healthy controls.

Keywords:

Oxidative stress precocious puberty premature thelarche thiol/disulfide homeostasis

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Last Updated: Jun 11, 2025

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Published on: June 28, 2024

Area of Science:

Biochemistry
Pediatric Endocrinology
Oxidative Stress Research

Background:

Oxidative products play roles in physiological processes.
Overproduction of oxidative products is implicated in disease etiology.
Thiol-disulfide homeostasis (TDH) is a key oxidative stress parameter.

Purpose of the Study:

To evaluate TDH in girls with premature thelarche (PT) and precocious puberty (PP).
To compare TDH parameters between girls with PT, PP, and healthy controls.
To determine correlations between TDH and hormonal levels (LH, FSH, E2).

Main Methods:

A case-control study involving 39 girls with PT, 41 girls with PP, and 46 healthy controls.
Evaluation of native thiol (NT), disulfide, and total thiol (TT) levels.
Correlation analysis with LH, FSH, E2, and ROC curve analysis.

Main Results:

Native thiol (NT), total thiol (TT), and NT/TT ratio were significantly higher in PT and PP groups compared to controls (p<0.01).
Disulfide/NT and disulfide/TT ratios were lower in PT and PP groups (p<0.05).
NT and TT levels showed significant discriminatory power for PT and PP groups (p<0.01).

Conclusions:

TDH is altered in girls experiencing PT and PP.
NT and TT levels show potential as clinical markers for differentiating PT and PP.
Further research with larger cohorts is needed to validate these findings.