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Antithrombin III antigen in human platelets.

M L Alhenc-Gelas, M Aiach, A Gorenflot

    Thrombosis and Haemostasis
    |October 30, 1985
    PubMed
    Summary
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    Human platelets contain antithrombin III (AT III), a key blood clotting inhibitor. Platelets release AT III and fibrinogen when stimulated, suggesting AT III is stored in platelet granules.

    Area of Science:

    • Hematology
    • Biochemistry
    • Thrombosis research

    Background:

    • Antithrombin III (AT III) is a crucial inhibitor of blood coagulation.
    • The localization and function of AT III within human platelets have not been fully elucidated.

    Purpose of the Study:

    • To investigate the presence and quantity of immunoreactive AT III in human platelets.
    • To determine if platelets release AT III upon stimulation and its potential storage location.

    Main Methods:

    • Quantification of AT III antigen in platelets from 17 healthy donors using competitive enzyme immunoassay.
    • Analysis of AT III release from platelets stimulated with arachidonic acid.

    Main Results:

    • Immunoreactive AT III was detected in human platelets, with levels ranging from 32 to 140 ng per 10(9) platelets (mean 70.3 +/- 27.3).

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  • Platelet stimulation with arachidonic acid induced the release of AT III antigen, along with fibrinogen.
  • Platelet AT III constitutes approximately 0.01% of total antithrombin in normal blood.

    • Conclusions:

    • Human platelets contain significant levels of AT III antigen.
    • Platelet AT III is released upon stimulation, similar to fibrinogen.
    • These findings suggest that AT III is stored within platelet granules, potentially playing a role in localized hemostasis.