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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
175
Potential therapies for non-coding RNAs in breast cancer
Ruonan Li1,2, Yuxin Ji1,2, Ruyin Ye1,3
1Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui, China.
Frontiers in Oncology
|October 7, 2024
Summary
This review explores non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), as promising therapeutic targets and biomarkers for breast cancer (BC). These molecules offer potential for developing novel diagnostic, prognostic, and treatment strategies for BC.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Breast cancer (BC) is a heterogeneous disease with complex pathogenesis and multiple risk factors.
- Current treatments include chemotherapy, hormonal therapy, targeted therapy, and immunotherapy, but new therapeutic targets are needed.
- Non-coding RNAs (ncRNAs) are frequently deregulated in human cancers, including BC, affecting gene expression and cellular pathways.
Purpose of the Study:
- To review the potential of ncRNAs as diagnostic and prognostic biomarkers in breast cancer.
- To explore the role of ncRNAs as therapeutic targets for novel breast cancer treatments.
- To highlight the significance of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in BC pathogenesis and therapy.
Main Methods:
- Literature review of recent sequencing and profiling studies on ncRNAs in breast cancer.
- Analysis of the regulatory roles of ncRNAs in cancer development and progression.
- Evaluation of the potential of ncRNAs for therapeutic drug development and targeted delivery.
Main Results:
- ncRNAs, specifically lncRNAs and miRNAs, show altered expression in breast cancer cell lines and tissues.
- ncRNAs can regulate multiple downstream genes and pathways, making them attractive targets.
- The potential of ncRNAs as biomarkers and therapeutic targets in breast cancer is significant.
Conclusions:
- ncRNAs represent a promising area for advancing breast cancer diagnostics and therapeutics.
- Further research into lncRNAs and miRNAs could lead to more effective breast cancer treatment strategies.
- Targeting ncRNAs offers a novel approach to combatting breast cancer heterogeneity and improving patient outcomes.
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