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Updated: Jun 11, 2025

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
Mass spectrometry reflects key aspects of copper-amyloid β chemistry
Sarah Brandner1, Tanja Habeck1, Frederik Lermyte1
1Department of Chemistry, Clemens-Schöpf-Institute of Chemistry and Biochemistry, Technical University of Darmstadt, Peter-Grünberg-Strasse 4, 64287 Darmstadt, Germany. frederik.lermyte@tu-darmstadt.de.
Abstract:
Mass spectrometry is a powerful method to study protein complexes; however, biochemical reactions are typically beyond the scope of MS studies. Here, we have studied the gas-phase redox chemistry of the [copper(II) - amyloid β] complex and show that the sequence-dependence of this chemistry reflects key aspects of the known in vitro behaviour of different variants of the peptide.
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