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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

2
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
2
Tissue Transplantation01:24

Tissue Transplantation

341
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
341

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Related Experiment Video

Updated: Jun 11, 2025

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach
10:33

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach

Published on: May 23, 2025

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Establishing an upper extremity transplantation program: lessons learnt over 12 years.

Kevin J Zuo1, Alessandra Zaccardelli2, Simon G Talbot3

  • 1Division of Hand & Upper Extremity Surgery, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School.

Current Opinion in Organ Transplantation
|October 7, 2024
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Summary
This summary is machine-generated.

Setting up a successful hand transplantation program requires careful planning and continuous learning. Vascularized composite allotransplantation (VCA) of the upper limb offers improved outcomes for selected patients.

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Area of Science:

  • Surgical innovation in transplantation medicine.
  • Regenerative medicine and reconstructive surgery.
  • Immunology and post-transplant care.

Background:

  • Hand transplantation, a form of vascularized composite allotransplantation (VCA), has evolved over two decades.
  • Global experience demonstrates improved functional outcomes and quality of life for carefully selected patients.
  • Over 30 patients in the USA have benefited from hand transplantation, with approximately 80% long-term success rates.

Purpose of the Study:

  • To educate emerging hand transplantation programs on critical lessons learned.
  • To provide guidance on establishing and maintaining a successful hand transplantation program.
  • To share personal experience in vascularized composite allotransplantation (VCA) of the upper limb.

Main Methods:

  • Review of personal experience from an early hand transplant program.
  • Highlighting key aspects of VCA team assembly and logistics.
  • Discussing patient selection, perioperative planning, surgical procedures, and postoperative management.

Main Results:

  • VCA of the upper limb has shown significant success in improving patient function and quality of life.
  • Experience includes four bilateral upper extremity allotransplant cases.
  • The review details essential components for program success, from team building to long-term care.

Conclusions:

  • Continuous learning and critical evaluation are vital for sustaining successful upper extremity VCA programs.
  • Optimizing patient selection and care ensures the best outcomes for this life-enhancing procedure.
  • Successful programs require ongoing refinement to identify and support the most suitable candidates.