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Updated: Jun 11, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Self-assembly and condensation of intermolecular poly(UG) RNA quadruplexes

Saeed Roschdi1, Eric J Montemayor1, Rahul Vivek1

  • 1Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

Nucleic Acids Research
|October 7, 2024
PubMed
Summary

Poly(UG) repeats in RNA self-assemble into gel condensates via quadruplex (G4) interactions. These structures, crucial for gene silencing in C. elegans, exhibit diverse topologies and handedness based on sequence length.

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