SubCELL: the landscape of subcellular compartment-specific molecular interactions

Area of Science:

• Molecular Biology
• Bioinformatics
• Cell Biology

Background:

• Subcellular compartment-specific molecular interactions (SCSIs) are fundamental to cellular functions, biological processes, and disease development.
• Existing databases lack comprehensive data on experimentally identified and inferred SCSIs.
• There is a need for a centralized resource detailing SCSIs for DNA, RNA, and proteins across species.

Purpose of the Study:

• To introduce SubCELL, a novel knowledge base for SCSIs.
• To provide experimentally identified SCSIs.
• To systematically illustrate inferred SCSIs and collect experimentally determined subcellular locations.

Main Methods:

• Curating and integrating experimental data on SCSIs.
• Employing established methods for inferring SCSIs.
• Compiling experimentally determined subcellular localization data for diverse species.

Main Results:

• Development and launch of the SubCELL knowledge base.
• Inclusion of the first collection of experimentally identified SCSIs.
• Systematic cataloging of a large number of inferred SCSIs.
• Integration of experimentally determined subcellular locations for DNA, RNA, and proteins.

Conclusions:

• SubCELL offers a unique and comprehensive resource for SCSIs.
• The database is expected to significantly advance molecular biology research.
• SubCELL is freely accessible, promoting wider scientific use and discovery.