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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

177
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
177

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An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
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Advances in stimuli-responsive injectable hydrogels for biomedical applications.

Xuebin Ma1,2, Kanaparedu P C Sekhar1, Peiyu Zhang1

  • 1Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China. pyzhang@sdu.edu.cn.

Biomaterials Science
|October 7, 2024
PubMed
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Stimuli-responsive injectable hydrogels offer precise, minimally invasive drug delivery for various biomedical applications. These advanced materials show great promise in tissue engineering and tumor treatment, with ongoing research addressing future challenges.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Injectable hydrogels are highly hydrated soft materials crucial for biomedicine.
  • Their in situ gelation and loading capabilities make them ideal for drug delivery, tissue engineering, wound dressing, and tumor treatment.

Purpose of the Study:

  • To summarize design strategies, advantages, and recent developments of stimuli-responsive injectable hydrogels.
  • To discuss challenges and future perspectives for these advanced biomaterials.

Main Methods:

  • Review of design strategies for stimuli-responsive injectable hydrogels.
  • Analysis of recent advancements in various biomedical fields.
  • Discussion of challenges and future research directions.

Main Results:

  • Stimuli-responsive injectable hydrogels exhibit significant advantages in biomedicine due to their adaptability to internal and external stimuli (temperature, pH, light, etc.).
  • These hydrogels are versatile for applications including drug delivery, tissue engineering, wound healing, and cancer therapy.

Conclusions:

  • Stimuli-responsive injectable hydrogels are promising advanced materials for diverse biomedical applications.
  • Further research is needed to overcome challenges and fully realize their therapeutic potential.