Investigating the Correlation Between Cognitive Function and Fasting Blood Sugar, Fasting Insulin Level and Insulin...

Area of Science:

• Neurology
• Endocrinology
• Metabolic Syndrome

Background:

• Cognitive impairment (CI) is a significant concern in multiple sclerosis (MS).
• Identifying factors influencing CI in MS patients is crucial for effective management.
• Metabolic markers are increasingly recognized for their potential impact on neurological health.

Purpose of the Study:

• To investigate the correlation between fasting blood sugar (FBS), fasting insulin levels, and insulin sensitivity (IS) with cognitive function in MS patients.
• To determine if metabolic factors can predict cognitive impairment in this population.

Main Methods:

• Cross-sectional study involving 85 MS patients.
• Insulin sensitivity assessed using the Quantitative Insulin Sensitivity Check Index (Quicki).
• Cognitive function evaluated using the Persian version of the Brief International Cognitive Assessment for MS (BICAMS).
• Spearman correlation analysis used to examine relationships between metabolic markers and cognitive scores.

Main Results:

• Higher FBS levels correlated negatively with performance on BVMT-R and BVMT-R-Delayed subtests.
• Elevated fasting insulin levels showed a negative correlation with the CVLT_II score.
• Insulin sensitivity positively correlated with CVLT-II and BVMT_R subtest scores.

Conclusions:

• Elevated fasting glucose and insulin levels, alongside reduced insulin sensitivity, are associated with cognitive impairment in MS.
• These metabolic factors may serve as potential predictors for cognitive decline in patients with multiple sclerosis.