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Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
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IL-17: A Critical Cytokine for Defense against Oral Candidiasis

Lucas Dos Santos Dias1, Michail S Lionakis1

  • 1Fungal Pathogenesis Section, Laboratory of Clinical Immunology & Microbiology (LCIM), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Journal of Immunology (Baltimore, Md. : 1950)
|October 7, 2024
PubMed

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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