TBAPy-based metal-organic frameworks with phosphate-induced fluorescence for detecting gossypol

Area of Science:

• Materials Science
• Nanotechnology
• Analytical Chemistry

Background:

• Achieving good dispersion of metal-organic frameworks (MOFs) is crucial for their diverse applications.
• Novel MOF nanocomposites require efficient synthesis and characterization for advanced functionalities.

Purpose of the Study:

• To synthesize a novel MOF nanocomposite, TBAPy-Yb, with excellent dispersion and fluorescence properties.
• To develop a sensitive and selective method for detecting gossypol (Gsp) using the synthesized MOF.
• To create a portable sensing platform for practical Gsp analysis.

Main Methods:

• Solvothermal synthesis of TBAPy-Yb using TBAPy and lanthanide metal ions.
• Characterization of TBAPy-Yb dispersion in phosphate buffer and its fluorescence emission at 435 nm.
• Gossypol (Gsp) detection via fluorescence quenching and color change, with a detection limit of 4.57 μM.

Main Results:

• TBAPy-Yb exhibited excellent dispersion in phosphate buffer and strong fluorescence emission.
• Gossypol (Gsp) was detected in the range of 10.0 to 70.0 μM with a distinct color change.
• The method showed high recovery rates (94.20%–104.90%) in cottonseed oil analysis, unaffected by potential interferences.

Conclusions:

• The developed TBAPy-Yb nanocomposite provides a sensitive and reliable platform for gossypol (Gsp) detection.
• The portable sensing system integrated with mobile phones offers a practical solution for Gsp analysis in real-world samples.
• This work highlights the potential of MOF-based nanomaterials in developing advanced analytical tools.