Related Experiment Video
Updated: Jun 11, 2025
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Human pegivirus -1 (HPgV-1) RNA frequency and genotype distribution in pediatric oncology patients with febrile
Anielly Sarana da Silva1, Gabriel Montenegro de Campos1, Gabriela Marengone Altizani2
1Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14051-140, Ribeirão Preto, SP, Brazil.
Insights
Human Pegivirus-1 (HPgV-1) RNA was detected in 23.3% of pediatric patients, including those with febrile neutropenia (FN). Further research is needed to understand HPgV-1
Area of Science:
- Virology
- Pediatric Oncology
- Infectious Diseases
Background:
- Human Pegivirus-1 (HPgV-1) is a prevalent, generally commensal virus in humans.
- The role and prevalence of HPgV-1 in pediatric patients with febrile neutropenia (FN), a common chemotherapy side effect, are not well understood.
Purpose of the Study:
- To determine the prevalence of HPgV-1 RNA in pediatric patients experiencing FN.
- To explore the potential association between HPgV-1 and FN in this vulnerable population.
Main Methods:
- Blood samples were collected from 30 pediatric patients: 15 with FN and 15 in a control group (undergoing treatment or in remission).
- HPgV-1 RNA detection was performed using molecular methods.
- Phylogenetic analysis was conducted to identify circulating HPgV-1 genotypes.
Main Results:
- HPgV-1 RNA was detected in 23.3% of all samples.
- Prevalence was slightly higher in the FN group (26.7%) compared to the control group (20.0%).
- Phylogenetic analysis identified HPgV-1 genotype 2 as the predominant strain, consistent with circulation in Brazil.
Conclusions:
- HPgV-1 RNA is present in pediatric patients, including those with FN.
- The findings raise questions about whether HPgV-1 is an incidental finding or plays a role in FN.
- Further research is crucial to clarify the implications of HPgV-1 in immunocompromised pediatric populations.
Abstract:
Human Pegivirus-1, typically regarded as a commensal virus, exhibits high prevalence in humans. Its frequency and impact on oncologic pediatric patients with febrile neutropenia (FN), a frequent chemotherapy complication, remains unexplored. In this study, we assessed HPgV-1 RNA prevalence in pediatric patients experiencing FN. Blood samples were collected from 30 children, 15 presenting FN and 15 comprising a control group of either undergoing treatment or in remission. Overall, HPgV-1 RNA was detected in 23.3 % of samples (26.7 % among FN patients and 20.0 % among those under treatment or in remission). Phylogenetic analysis unveiled HPgV-1 genotype 2 predominance among these samples, the most prevalent strain circulating in Brazil. Our findings prompt crucial inquiries into the role of HPgV-1 RNA in FN: is it an incidental finding and if it can influences this clinical entity? Further investigation is imperative to elucidate HPgV-1 implications in vulnerable patients cohorts, potentially informing new approaches and understanding viral dynamics in immunocompromised populations.
