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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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[Epigenetic changes in alcohol addiction and therapeutic perspectives]

Olivier Pierrefiche1

  • 1Inserm UMR1247, groupe de recherche sur l'alcool et les pharmacodépendances, centre universitaire de recherche en santé, université Picardie Jules-Verne, chemin du Thil, Amiens, France.

Annales Pharmaceutiques Francaises
|October 7, 2024
PubMed

Insights

Epigenetic modifications play a key role in alcohol use disorder (AUD). Exploring epidrugs offers a promising alternative to current treatments for AUD, potentially improving patient outcomes.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Context:

  • Alcohol Use Disorder (AUD) presents a significant public health challenge.
  • Current AUD treatments targeting membrane receptors show modest efficacy.
  • Emerging evidence highlights the crucial role of epigenetics in alcohol's effects.

Purpose:

  • To review experimental evidence on epigenetics and alcohol consumption across different ages in animal models and humans.
  • To assess the therapeutic potential of epidrugs for AUD.
  • To propose novel therapeutic strategies integrating psychedelics and epigenetic factors.

Summary:

  • Alcohol consumption significantly impacts the epigenome, influencing AUD development and progression.
  • Epidrugs, which modify epigenetic markers, represent a promising avenue for novel AUD therapies.
  • Research in animal models and human data supports the relevance of epigenetic interventions.

Impact:

  • This review underscores the potential of epigenetic therapies to offer a new paradigm for AUD treatment.
  • It bridges the gap between fundamental epigenetic research and clinical application.
  • Suggests innovative therapeutic combinations for future AUD management.
Keywords:
ADNAdolescentAdultAdulteDNAHistonePsychedelicPsychédélique

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