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Updated: Jun 11, 2025

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
Published on: July 28, 2022
Surfaces as frameworks for intracellular organization
Germán Rivas1, Allen P Minton2
1CIB Margarita Salas - Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
None:
A large fraction of soluble protein within the interior of living cells may reversibly associate with structural elements, including proteinaceous fibers and phospholipid membranes. In this opinion, we present theoretical and experimental evidence that many of these associations are due to nonspecific attraction between the protein and the surface of the fiber or membrane, and that such associations may lead to substantial changes in the association state of the adsorbed proteins, the biological function of the adsorbed proteins, and the distribution of these proteins between the many microenvironments existing within the cell.
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