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Hereditary haemorrhagic telangiectasia type 1 complicated by recurrent deep-seated MSSA infections necessitating

Evan Paul Tracy1, Iyanujesu Adereti2, Justin Chu3

  • 1Medicine, University of Louisville, Louisville, Kentucky, USA.

BMJ Case Reports
|October 7, 2024
PubMed

Hereditary haemorrhagic telangiectasia (HHT) leads to arteriovenous malformations (AVM) that increase the risk of haemorrhage and cause right-left shunting bypassing the reticuloendothelial system increasing the risk for recurrent infections. A 60+ year old male patient with HHT type 1 (status post six pulmonary AVM coiled embolisations) with epistaxis presented with intractable back pain, methicillin-sensitive Staphylococcus aureus (MSSA) bacteraemia and spinal MRI revealing spondylodiskitis and L4-L5 epidural phlegmon. He has an extensive history of deep-seated infections including two prior spinal infections, two joint infections and one muscular abscess-all with MSSA. The patient was treated with 6 weeks of intravenous nafcillin with symptom resolution. Infectious disease prescribed cefalexin 500 mg daily for suppression of infection recurrence considering his extensive deep-seated infection history and multiple risk factors. This case raises important questions about preventative antimicrobial management of high-risk patients with HHT, which is a grey area in current international HHT guidelines.

Keywords:
ArteriesBack painBone and joint infectionsCardiovascular systemInfections

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