Related Experiment Video
Updated: Jun 11, 2025
06:07
Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
Published on: March 28, 2025
208
Histone lactylation drives CD8+ T cell metabolism and function.
Deblina Raychaudhuri1, Pratishtha Singh1, Bidisha Chakraborty1
1Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nature Immunology
|October 7, 2024
Summary
Histone lactylation, specifically H3K18la and H3K9la, is enriched in CD8+ T cells and regulates their function. Modulating these marks impacts antitumor immunity, revealing their critical role in T cell responses.
Area of Science:
- Immunology
- Epigenetics
- Metabolic pathways
Background:
- CD8+ T cell activation and function are linked to metabolic pathways producing lactate.
- Lactylation, a histone modification from lactate, has unknown relevance in CD8+ T cells.
Purpose of the Study:
- To investigate the role of histone lactylation (H3K18la and H3K9la) in CD8+ T cell activation and function.
- To explore the impact of modulating histone lactylation on CD8+ T cell effector functions and antitumor immunity.
Main Methods:
- Analysis of H3K18la and H3K9la enrichment in human and mouse CD8+ T cells.
- Investigation of distinct lactylation patterns in CD8+ T cell subsets.
- Modulation of lactylation via metabolic and epigenetic targeting in preclinical models.
Main Results:
- H3K18la and H3K9la are enriched in CD8+ T cells and initiate transcription of key functional genes.
- Distinct H3K18la and H3K9la patterns correlate with specific CD8+ T cell metabolic profiles.
- Modulation of H3K18la and H3K9la influences CD8+ T cell effector functions, including antitumor immunity.
Conclusions:
- H3K18la and H3K9la are critical epigenetic marks in CD8+ T cells.
- Histone lactylation plays a significant role in regulating CD8+ T cell function and antitumor immunity.
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