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Analysis of Gyimes Csango population samples on a high-resolution genome-wide basis

Analysis of Gyimes Csango population samples on a high-resolution genome-wide basis

Zsolt Bánfai ¹, Gergely Büki ², Valerián Ádám ², Katalin Sümegi ^2,3, András Szabó ², Kinga Hadzsiev ², Krisztián Erős ³, Ferenc Gallyas ³, Attila Miseta ⁴, Miklós Kásler ⁵, Béla Melegh ⁶

Zsolt Bánfai ¹, Gergely Büki ², Valerián Ádám ²

¹Department of Medical Genetics, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary. banfai.zsolt@pte.hu.
²Department of Medical Genetics, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.
³Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.
⁴Department of Laboratory Medicine, Medical School, University of Pécs, Ifjúság út 13, Pécs, H-7624, Hungary.
⁵Institute of Hungarian Research, Andrássy út 64, Budapest, H-1062, Hungary.
⁶Department of Medical Genetics, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary. melegh.bela@pte.hu.

⁰Department of Medical Genetics, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary. banfai.zsolt@pte.hu.

Bmc Genomics +

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October 7, 2024

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View abstract on PubMed

Summary

This summary is machine-generated.

Genetic analysis reveals Csango subgroups in Romania exhibit distinct, though similar, levels of isolation. Gyimes Csangos show weaker isolation than Moldavian Csangos, with a notable East Asian/Siberian Turkic ancestral component.

Area Of Science

Population Genetics
Human Ancestry
European Ethnography

Background

The Csangos are an East-Central European ethnographic group in Romania, traditionally divided into Moldavian, Gyimes, and Burzenland subpopulations.
Previous research indicated unique East Asian/Siberian Turkic ancestry in Moldavian Csangos, potentially illuminating Hungarian ethnic history.
This study focuses on Gyimes Csangos, a distinct and isolated subgroup, comparing their genome-wide genetic makeup with Moldavian Csangos.

Purpose Of The Study

To conduct the first genomic analysis of Gyimes Csangos.
To compare the genetic profiles of Moldavian and Gyimes Csango subgroups.
To investigate the genetic isolation of Csangos on a genome-wide single nucleotide polymorphism (SNP) basis and assess Gyimes Csango isolation.

Main Methods

Genome-wide SNP analysis.
Allele-frequency-based genetic comparison.
Haplotype-based genetic comparison.

Main Results

Both Csango groups exhibit slight genetic differences from each other.
Genetic isolation was confirmed for Moldavian Csangos and found to be present, though weaker, in Gyimes Csangos.
Gyimes Csangos displayed a stronger East European or Asian-derived ancestry component.

Conclusions

Gyimes Csangos demonstrate a degree of genetic isolation comparable to Moldavian Csangos.
The Asian ancestry identified in Moldavian Csangos appears to be present to a greater extent in Gyimes Csangos.
These findings contribute to understanding the genetic landscape and historical migrations within East-Central Europe.

Keywords:

Allele frequency Ancestry Csango DNA microarray Haplotype Population structure

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