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Related Concept Videos

Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

399
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
399

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Oral/Perioral Reactions to Injectable Soft Tissue Fillers: A Clinicopathological Multicentric Study.

Fábio Ramoa Pires1, Aurélio Marcos Tsutyia Said2, Juliana de Noronha Santos Netto3

  • 1Oral Pathology, School of Dentistry, Rio de Janeiro State University, and Post Graduation Program in Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil.

Oral Diseases
|October 8, 2024
PubMed
Summary

Oral reactions to injectable soft tissue fillers often present as asymptomatic nodules in adult females. Histological analysis revealed common fillers like silicone and polymethylmethacrylate, with granulomas and giant cells being frequent findings.

Keywords:
fillinghyaluronic acidlipspolymethylmetacrylatereactionssilicone

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Area of Science:

  • Oral pathology
  • Dermatology
  • Plastic surgery

Background:

  • Injectable soft tissue fillers are widely used for cosmetic purposes.
  • Adverse reactions can occur, necessitating detailed characterization.
  • Oral manifestations of filler reactions require specific diagnostic considerations.

Purpose of the Study:

  • To analyze the clinicopathological characteristics of oral reactions to injectable soft tissue fillers.
  • To identify common filler materials and histological patterns associated with these reactions.
  • To provide insights for clinicians managing such cases.

Main Methods:

  • Retrospective case series analysis of oral reactions to injectable soft tissue fillers.
  • Inclusion of cases from eight pathology laboratories.
  • Review of laboratory charts and hematoxylin and eosin-stained histological slides.

Main Results:

  • 151 patients (90.1% female, mean age 54.9 years) with oral filler reactions.
  • Lips were the most frequent site (72.8%), with asymptomatic nodules being common.
  • Silicone, polymethylmethacrylate, and hyaluronic acid were the most frequent fillers; granulomas and giant cells were prevalent histologically.

Conclusions:

  • Oral reactions to fillers are more common in adult females, often presenting as asymptomatic lip nodules.
  • Specific filler materials are associated with distinct histological findings (e.g., foamy macrophages with silicone, giant cells with polymethylmethacrylate).
  • Clinicians should consider filler reactions in the differential diagnosis of submucosal lip nodules.