Comparative Transcriptomes of Canine and Human Prostate Cancers Identify Mediators of Castration Resistance

Marcela Riveros Angel ¹, Bernard Séguin ², Christiane V Löhr ³

⁰Department of Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, Oregon, USA.

Veterinary and Comparative Oncology +

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October 8, 2024

View abstract on PubMed

Summary

Canine and human prostate cancers share molecular similarities, particularly in castration-resistant prostate cancer (CRPC). The interferon pathway may be a key factor in CRPC development, offering a potential new therapeutic target.

Area Of Science

Comparative oncology
Molecular biology
Genomics

Background

Prostate cancer, especially castration-resistant prostate cancer (CRPC), remains a significant health concern in humans.
Canine prostatic carcinoma in castrated dogs mirrors human CRPC, presenting an opportunity for comparative study.

Purpose Of The Study

To identify molecular parallels between canine prostatic carcinoma and human CRPC.
To explore potential shared pathways driving advanced prostate cancer progression.

Main Methods

Comparative transcriptomic analysis of gene expression profiles in canine and human prostate cancer samples.
Protein-protein interaction network analysis to identify functional gene relationships.

Main Results

Canine prostatic carcinoma exhibits an androgen-indifferent phenotype, similar to human CRPC.
ISG15 and AZGP1 showed consistent differential expression in both species.
Five identified genes (ISG15, AZGP1, GPX3, S100P, IFITM1) are part of an interferon-induced gene network.

Conclusions

The interferon pathway is implicated in the development and progression of CRPC in both dogs and humans.
These findings suggest a potential novel therapeutic strategy targeting the interferon pathway for CRPC treatment.

Keywords:

androgen cancer canine castration‐resistant prostate cancer transcriptome