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Published on: January 7, 2019
RETRACTION: Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis-Like Changes in Knee
Retraction:
R. Kc, X. Li, R. M. Voigt, M. B. Ellman, K. C. Summa, M. H. Vitaterna, A. Keshavarizian, F. W. Turek, Q.-J. Meng, G. S. Stein, A. J. van Wijnen, D. Chen, C. B. Forsyth, and H.-J. Im, "Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis-Like Changes in Knee Joint," Journal of Cellular Physiology 230, no. 9 (2015): 2174-2183, https://doi.org/10.1002/jcp.24946. The above article, published online on 5 February 2015 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Robert Heath; and Wiley Periodicals LLC. The retraction has occurred due to concerns related to the data presented in the article raised by the Office of Research Compliance at Rush University Medical Center following an investigation jointly conducted by Rush University and the Jesse Brown Veterans Affairs Medical Center (JBVAMC). Specifically, image elements of the experimental data in Figure 4 A were found to have been used by the same author(s) for publication elsewhere in a different scientific context. The corresponding author, Dr. Hee-Jeong Im Sampen, has been informed of the decision to retract but did not agree with it, as she is confident that any errors in the publication do not impact the reliability of the paper's findings. She also advised the editors that she stands ready to cooperate fully to make any necessary corrections. However, the article is retracted as the editors lost trust in the accuracy of the data and consider the conclusions invalid.
Insights
This study investigated how disrupting the circadian rhythm in mice affects knee joint health, finding it predisposes them to osteoarthritis-like changes. The article was retracted due to data integrity concerns.
Area of Science:
- Chronobiology
- Orthopedics
- Cellular Physiology
Context:
- The study explored the link between environmental disruption of circadian rhythms and musculoskeletal health.
- Previous research has indicated potential connections between biological clock function and joint integrity.
Purpose:
- To investigate the impact of disrupted circadian rhythms on the development of osteoarthritis-like changes in mouse knee joints.
- To establish a potential etiological link between circadian disruption and joint degeneration.
Summary:
- Environmental disruption of the circadian rhythm in mice led to the development of osteoarthritis-like changes in the knee joint.
- Specific alterations were observed in the joint tissues, suggesting a direct biological consequence of circadian misalignment.
- The findings suggested that maintaining a regular circadian rhythm is crucial for joint health.
Impact:
- The article was retracted due to concerns regarding the accuracy and integrity of the presented experimental data, specifically image elements.
- Concerns were raised about the reuse of image data in different scientific contexts, leading to a loss of trust in the findings.
- Despite the retraction, the initial research aimed to highlight the importance of circadian rhythm in preventing joint diseases like osteoarthritis.
