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Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
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Association between triglyceride glycemic index and ejection fraction preserved heart failure in hypertensive

Xue-Feng Shan1,2,3, Long Yang1, Xiao-Ming Gao1,2,3

  • 1State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia; Pediatric Cardiothoracic Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Peerj
|October 8, 2024
PubMed

Insights

The triglyceride-glucose (TyG) index, a marker for insulin resistance, is significantly associated with heart failure with preserved ejection fraction (HFpEF) in patients with essential hypertension. This finding suggests metabolic dysfunction plays a key role in HFpEF development.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Hypertension Research

Background:

  • The triglyceride-glucose (TyG) index is a recognized predictor of cardiovascular disease and a surrogate for insulin resistance (IR).
  • The relationship between the TyG index and heart failure with preserved ejection fraction (HFpEF) in essential hypertension patients was previously unestablished.

Purpose of the Study:

  • To investigate the correlation between the TyG index and HFpEF in patients diagnosed with essential hypertension.
  • To evaluate the predictive value of the TyG index for HFpEF in this population.

Main Methods:

  • A retrospective study of 992 hypertensive patients was conducted.
  • Spearman's correlation, logistic regression, restricted cubic splines, and ROC curve analyses were employed.
  • Patients were stratified by TyG index tertiles to assess risk factors.

Main Results:

  • Higher TyG index tertiles were linked to increased HFpEF risk factors like age, BMI, SBP, NT-proBNP, and LVMI.
  • A significant independent association was found between the TyG index and HFpEF (OR 5.127).
  • A nonlinear, S-shaped relationship existed between TyG index and HFpEF incidence; TyG index, NT-proBNP, and LVMI showed good predictive ability, with the TyG+LVMI combination being strongest (AUC 0.907).

Conclusions:

  • Insulin resistance, indicated by the TyG index, is significantly associated with HFpEF development in hypertensive individuals.
  • Metabolic dysfunction is crucial in HFpEF pathophysiology.
  • A comprehensive approach to cardiovascular risk management in hypertension should consider metabolic factors.
Abstract

Keywords:
Essential hypertensionHeart failure with preserved ejection fractionInsulin resistanceTriglyceride glucose index

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