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Differentiated Thyroid Cancers with Synchronous Second Primary Cancers: Case Series.

Devarajan Jebin Aaron1,2, Priyank Rathod1,3, Shailee Mehta1,4

  • 1The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
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PubMed
Summary

Synchronous second primary cancers (SSPC) with differentiated thyroid cancer (DTC) are rare. Head and neck squamous cell carcinoma was the most common SSPC found in patients with DTC.

Keywords:
Differentiated thyroid cancersPapillary thyroid carcinomaSynchronous oral primary cancersSynchronous second primary cancers

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Area of Science:

  • Oncology
  • Endocrinology
  • Head and Neck Surgery

Background:

  • Synchronous second primary cancer (SSPC) occurring with differentiated thyroid cancer (DTC) is exceptionally rare.
  • Existing literature consists of limited case reports and series, highlighting a need for more comprehensive data.

Purpose of the Study:

  • To detail the clinicopathological characteristics of patients diagnosed with both DTC and SSPC.
  • To identify common patterns and outcomes in this rare dual-cancer presentation.

Main Methods:

  • A single-center retrospective study was conducted.
  • Data from January 2016 to July 2023 were collected for patients with DTC and SSPC.
  • Demographic, clinicopathological, and survival data were analyzed.

Main Results:

  • Twelve patients with DTC and SSPC were identified, all with papillary thyroid cancer.
  • Head and neck squamous cell carcinoma was the most frequent SSPC (10 patients).
  • Median overall survival was 40.97 months with a median follow-up of 25.55 months.

Conclusions:

  • Head and neck squamous cell carcinoma is the predominant SSPC associated with DTC.
  • The rarity of these cases underscores the importance of multidisciplinary team discussions for optimal management strategies.