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Gut microbiota and functional outcome after ischemic stroke: a Mendelian randomization study.

Dian Qu1, Deming Jiang2, Yan Xin1

  • 1Department of Neurology, Harbin 242 Hospital, Harbin, Heilongjiang, China.

Frontiers in Immunology
|October 8, 2024
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Summary

This study used Mendelian randomization to investigate the gut microbiota

Keywords:
Mendelian randomizationfunctional outcomegut microbiotaischemic strokesynapse function

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Area of Science:

  • Neuroscience
  • Microbiology
  • Genetics

Background:

  • Gut microbiota dysbiosis is linked to clinical prognosis via unknown mechanisms.
  • The causal relationship between gut microbiota and functional outcomes post-ischemic stroke is unclear.

Purpose of the Study:

  • To investigate the causal association between gut microbiota and functional outcomes after ischemic stroke using Mendelian randomization (MR).

Main Methods:

  • Utilized genetic instrumental variables for 211 bacterial traits from the MiBioGen consortium (N=18,340).
  • Analyzed genome-wide association studies (GWAS) data for overall stroke outcome and motor recovery.
  • Employed the inverse variance weighted method for causal association estimation and enrichment analysis.

Main Results:

  • Specific gut bacteria families (Peptostreptococcaceae, Oxalobacteraceae) and genera (LachnospiraceaeNK4A136 group, LachnospiraceaeUCG004, Odoribacter, RuminococcaceaeUCG005, RuminococcaceaeUCG014) showed associations with functional outcomes and motor recovery.
  • The order Enterobacteriales and family Enterobacteriaceae were linked to motor weakness.
  • Enrichment analysis suggested a role for synapse regulation in the gut microbiota's effect on stroke outcomes.

Conclusions:

  • Provides genetic evidence that gut microbiota, particularly short-chain fatty acid producers, influences stroke prognosis by mediating synapse function.
  • Suggests that modulating gut microbiota composition may enhance recovery after ischemic stroke.