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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Proficiency testing within Eurotransplant.

Yvonne M Zoet1, Sebastiaan Heidt1, Marissa J H van der Linden-van Oevelen1

  • 1Immunology-ETRL, Leiden University Medical Center (LUMC), Leiden, Netherlands.

Frontiers in Genetics
|October 8, 2024
PubMed
Summary
This summary is machine-generated.

The Eurotransplant external proficiency testing (EPT) program ensures consistent quality in histocompatibility testing across eight European countries. This program monitors and corrects laboratory performance, leading to uniform testing standards.

Keywords:
Eurotransplanthistocompatibility testingpatient-based casesproficiency testsolid organ transplantation

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Area of Science:

  • Transplantation immunology
  • Clinical laboratory science

Background:

  • Eurotransplant coordinates international organ allocation among eight European countries.
  • Accreditation (EFI/ASHI) and participation in the Eurotransplant external proficiency testing (EPT) program are mandatory for affiliated HLA laboratories.
  • The EPT program, organized by the Eurotransplant Reference Laboratory (ETRL), has a long history dating back to 1978.

Purpose of the Study:

  • To describe the Eurotransplant external proficiency testing (EPT) program.
  • To highlight the program's role in monitoring and ensuring the quality of histocompatibility testing.
  • To demonstrate the program's effectiveness in achieving uniform quality standards.

Main Methods:

  • The EPT program includes schemes for HLA typing (serology), complement-dependent cytotoxicity (CDC) crossmatching, and HLA-specific antibody detection and identification.
  • Laboratory results are submitted via a web-based application, with assessed results published online.
  • An additional 'patient-based cases' component was introduced in 2016, with results discussed at an annual meeting.

Main Results:

  • The EPT program allows for continuous monitoring and correction of HLA laboratory performance.
  • Consistent results across participating laboratories indicate the program's effectiveness.
  • Published results and annual meetings facilitate quality improvement and knowledge sharing.

Conclusions:

  • The Eurotransplant EPT program is an efficient tool for standardizing histocompatibility testing quality.
  • Consistent participation and assessment ensure a uniform level of laboratory performance.
  • The program contributes significantly to the reliability of organ allocation within Eurotransplant.