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  3. Outcome Of A Novel Drug Combination In The Medical Management Of Oral Submucous Fibrosis Patients: A Retrospective Cohort Study.
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  3. Outcome Of A Novel Drug Combination In The Medical Management Of Oral Submucous Fibrosis Patients: A Retrospective Cohort Study.

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Outcome of a Novel Drug Combination in the Medical Management of Oral Submucous Fibrosis Patients: A Retrospective

Kaushik H Pethani1, Samruddhi J Borate2

  • 1Director, The Facial Surgery Hospital, Rajkot, Gujarat India.

Journal of Maxillofacial and Oral Surgery
|October 8, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

A new drug combination significantly improved symptoms for oral submucous fibrosis (OSMF) patients. The treatment enhanced mouth opening, tongue protrusion, and reduced burning sensations across all grades of OSMF.

Keywords:
AntioxidantsMedical managementOral submucous fibrosisSMF CARE®

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Area of Science:

  • Oral Medicine
  • Pharmacology
  • Clinical Research

Background:

  • Oral submucous fibrosis (OSMF) is a chronic, potentially malignant disorder.
  • Current management options for OSMF have limitations in efficacy.
  • There is a need for effective therapeutic strategies to manage OSMF symptoms.

Purpose of the Study:

  • To evaluate the efficacy of a novel drug combination for oral submucous fibrosis (OSMF).
  • To assess the impact of the drug combination on key clinical parameters in OSMF patients.

Main Methods:

  • Retrospective cohort study of 89 patients diagnosed with OSMF (Grades I, II, III).
  • Patients received the new drug combination for 6 months.
  • Clinical parameters including burning sensation, mouth opening, and tongue protrusion were assessed retrospectively at multiple time points (1, 3, 6, and 12 months).

Main Results:

  • Significant improvements in mouth opening and tongue protrusion were observed across all OSMF grades from baseline to 12 months post-treatment (p < 0.0001).
  • A significant reduction in burning sensation score was noted in all grades from baseline to 12 months post-treatment (p < 0.0001).
  • Improvements were consistent and statistically significant on intra- and intergroup comparisons.

Conclusions:

  • The novel drug combination demonstrates significant efficacy in managing oral submucous fibrosis.
  • The treatment effectively improves burning sensation, mouth opening, and tongue protrusion in OSMF patients.
  • The positive therapeutic effects are sustained up to one year post-treatment.