Successful Treatment of Hyaluronic Acid-Induced Facial Necrosis With Intravenous Dinoprostone

There is an increasing interest in the use of facial dermal filler injections, such as hyaluronic acid, for esthetic and rejuvenation purposes. However, their use is associated with a potential risk of complications. We report the case of a woman in her thirties, with rapidly evolving facial skin necrosis following accidental intravascular injection of hyaluronic acid and/or extravascular compression. The necrosis worsened despite early repeated local injections of hyaluronidase. However, rapid and favorable clinical evolution was observed after the patient was treated for seven consecutive days with intravenous infusion of dinoprostone (a prostaglandin E2).