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Updated: Jun 11, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-Light Photoredox-Catalyzed Direct Decarboxylative Functionalization of α-Keto Acids
Huangbin Sun1, Qianfan Zhang1, Jie Tang1
1State Key Laboratory of Chemo/Biosensing and Chemometrics, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.
Abstract:
A novel and environmentally friendly photocatalytic strategy is presented for generating acyl radicals from benzoylformic acids, which are subsequently trapped by various sulfone-based SOMOphiles. This strategy provides a robust toolkit to access a variety of synthetically important functionalized aryl-ketone derivatives, which efficiently and directly construct acyl-S, acyl-Se, acyl-C, and acyl-N bonds. The broad substrate scope, excellent functional group compatibility, and mild reaction conditions make this protocol practical and attractive.
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