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Loperamide induced acute pancreatitis in pediatrics
Irish Medical Journal
|October 8, 2024
Summary
Accidental ingestion of loperamide hydrochloride in a 13-year-old boy led to acute pancreatitis. This case highlights the first pediatric instance of loperamide-induced pancreatitis, emphasizing the drug's potential risks.
Area of Science:
- Pediatric Gastroenterology
- Toxicology
Background:
- Loperamide hydrochloride, an over-the-counter antidiarrheal, is an opioid-receptor agonist.
- While generally safe at therapeutic doses, supratherapeutic ingestion can lead to severe adverse effects.
Observation:
- A 13-year-old male presented with abdominal pain after ingesting 12 mg of loperamide hydrochloride.
- Elevated lipase and amylase levels confirmed acute pancreatitis, with other causes ruled out.
Findings:
- The patient was diagnosed with acute pancreatitis secondary to loperamide use.
- Pathophysiology involves μ-opioid receptor agonism, leading to sphincter of Oddi dysfunction and pancreatic duct obstruction.
Implications:
- This report details the first pediatric case of loperamide-induced acute pancreatitis.
- It underscores the importance of recognizing loperamide's potential toxicity in pediatric overdose scenarios.
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