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Updated: Jun 11, 2025
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Visible-Light-Triggered Radical-Addition/Ring-Opening Cascade Reactions of 2H-Indazoles to Access
Zhenhua Li1,2, Longfeng Yuan1, Yingyan Cao1
1College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Abstract:
A series of asymmetric azobenzenes have been synthesized by radical-addition/ring-opening cascade reactions from 2H-indazole in the presence of PIFA and alcohols under blue light irradiation and nitrogen protection. Furthermore, a wide range of functional groups were tolerated and the corresponding products were obtained in 30% to 95% isolated yields. The protocol is characterized by its visible-light initiation, avoidance of metals and photocatalysts, mild reaction conditions, and may find potential use in materials science and medicinal chemistry.
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04:38Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
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