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Published on: November 28, 2019
Transforming growth factor-β in tumor microenvironment: Understanding its impact on monocytes and macrophages for its
Tetiana Hourani1, Amit Sharma2,3, Rodney B Luwor4,5,6
1Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Australia.
Abstract:
TGF-β is a pivotal cytokine that orchestrates various aspects of cancer progression, including tumor growth, metastasis, and immune evasion. In this review, we present a comprehensive overview of the multifaceted role of transforming growth factor β (TGF-β) in cancer biology, focusing on its intricate interactions with monocytes and macrophages within the tumor microenvironment (TME). We specifically discuss how TGF-β modulates monocyte and macrophage activities, leading to immunosuppression and tumor progression. We conclude with the current translational and clinical efforts targeting TGF-β, recognizing the promising role of this strategy in immunooncology.
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