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Aerobic Physical Activity and Depression Among Patients With Cancer: A Systematic Review and Meta-Analysis
Matthew Kulchycki1, Henry Ratul Halder2,3, Nicole Askin4
1Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
JAMA Network Open
|October 8, 2024
Summary
Aerobic physical activity (APA) significantly reduces depression in cancer patients. This meta-analysis found APA associated with modest short-term and long-term improvements in depressive symptoms, enhancing quality of life.
Area of Science:
- Oncology
- Psychiatry
- Exercise Science
Background:
- Depression is common in cancer patients, impacting quality of life and survival.
- Aerobic physical activity (APA) is effective for depression in the general population, but its role in cancer patients needs more research.
Purpose of the Study:
- To evaluate if APA reduces depression severity in cancer patients.
- Synthesize data from randomized clinical trials (RCTs) to assess APA's effectiveness.
Main Methods:
- Systematic review and meta-analysis of 25 RCTs (1931 adults with cancer).
- Searched six databases (MEDLINE, Embase, etc.) for studies published up to July 2023.
- Assessed risk of bias using Cochrane Risk of Bias Tool v2 and followed PRISMA guidelines.
Main Results:
- APA was linked to decreased self-reported depression in cancer patients (SMD -0.38).
- Significant reductions observed in short-term (primary outcome) and long-term (secondary outcome) depression.
- No significant effect found for medium-term depression.
Conclusions:
- Aerobic physical activity shows modest short-term and long-term benefits for reducing depression in cancer patients.
- Further research is needed to explore APA combined with other strategies for diverse cancer populations.
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